The reason and solution of the crack of powder tablet press

The reason and solution of the crack of powder tablet press

1, the cause of the powder tablet machine

(1) compressibility of materials

The characteristics of the raw material, especially the crystal form.

Material adhesion, elastic deformation of the recovery of the moment more than the cohesion between the particles, resulting in a split.

The compressibility of the prescription is not good, which will lead to insufficient hardness of the tablet. If you blindly increase the pressure to increase the hardness under such circumstances, not only the hardness will not increase, but also the top crack will occur.

(2) process and equipment parameters

Particle properties: the particles are small, too much fine powder, the gas in the particles cannot be effectively removed in the process of tablet pressing. When the pressure is removed, the air inside the tablet expands and causes the split.

Pressure and speed: if the pressure is too high, the rebound force will also cause the tear. Most of the domestic tablet press design of the pre-pressure wheel is small, the main pressure wheel is very large, in the pressure of special-shaped tablets and Chinese medicine tablets often due to insufficient exhaust material, may appear the risk of split. For products with direct powder compression, adequate exhaust during precompression is particularly important.

Pressing die: the pressure is not uniform because the die is not in accordance with the requirements and the die ring.

Pressure room environment: pressure room temperature low, low humidity, also easy to cause a split.

2. Suggestions on the solution of powder tablet pressing machine

Raw material processing: raw material crushing, even micronization. By using wet or dry granulation process, raw materials are exposed to particles as much as possible through granulation to reduce the impact of raw materials on compressibility.

Improve the compressibility of materials: replace the auxiliary materials with better compressibility, reduce the speed of mixing and cutting when granulating; Or use fluidized bed granulation, not only improve the compressibility but also promote the increase of dissolution. The addition of micro-powder silica gel can obviously improve the compressibility of the particles and the hardness of the wafers under low pressure.

Improve the adhesion of materials: increase the concentration or dosage of adhesives, made of hard particles, this can increase the mechanical force of particle adhesion, thus improving the adhesion of materials. Particles should not be too large and hard, which may cause shadows and pockmarks. Reduce drying time and increase moisture. Compare the compressibility of materials with different drying time and moisture. Particles are too dry will appear, but in general, 1~3% can be pressed out of qualified pieces. Examine the way adhesives are added. Adhesive particle size reduction or in the form of solution, better induced adhesion. If wet granulation, can add inside and outside together. Can choose a stronger adhesive, such as HPMC, PVP, HPC, etc.

Guangdong Rich Packing professional production of powder tablet press, there is a need to contact us.