Common problems and solutions of tablet press machine

Common problems and solutions of tablet press machine

A tablet press is a machine that presses granule or powdery material into tablets by punch in the die hole. However, in the production process of the tablet, there are occasionally users reported the results of the tablet is not smooth. Here are two common problems with tablet pressing, and corresponding solutions.

Effervescent sheet press loose sheet phenomenon

The drug comminution fineness is not enough, the fiber or the elastic medicine or the oil component content is more and the mixture is not uniform will cause the loose piece phenomenon. The medicine can be crushed through 100 mesh screen, choose the adhesive with strong viscosity, increase the pressure of the tablet press appropriately, increase the absorption of oil drugs to be fully mixed and other methods to overcome.

Adhesive or wetting agent dosage is insufficient or the choice is improper, causes the grain texture to be loose or the grain thickness distribution is not uniform, the coarse grain and the fine grain stratification. Can choose the appropriate adhesive or increase the dosage, improve the pelletizing process, more stirring soft materials, mixed particles and other methods to overcome.

The water content of particles is too little, the excessively dry particles have greater elasticity, and the drug containing crystal water loses more crystal water in the process of particle drying, making the particles brittle and easy to loosen the lobes. Therefore, the water content of granule should be controlled according to different varieties. If the particles are too dry, spray an appropriate amount of dilute ethanol (50%-60%), mix and then press the tablets.

The phenomenon of loose tablets may also be related to the nature of the drug itself. For example, tablets with high density pressure have certain hardness, but they can not withstand collision and shaking; The fluidity of particles is poor, and the particles filled into the mold hole are not uniform; Or there are large or particles, debris blocking the scraper and cutting mouth, affecting the amount of filling.

In addition, pressing machine will also affect the effect of pressing. If the pressure is too small, the punch length of the multi-stamping machine is not equal, the speed is too fast or the particles in the hopper more or less. It can be overcome by adjusting the pressure, checking whether the die is complete, adjusting the speed, adding particles to keep a certain amount of stock in the hopper and so on.

Chinese medicine pressing machine split phenomenon

When the tablet is shaken or placed, a crack from the waist is called loin fissure; Those that crack from the top are called apical fissure, and loin fissure and apical fissure are always called lobes.

The drug itself is more elastic, fibrous drugs or because of the oil component. Sugar powder can be added to reduce the fiber elasticity, strengthen the adhesion or increase the absorbents of oil drugs, fully mixed after pressing tablets.

Adhesive or wetting agent is not appropriate or the dosage is not enough, particles in the tablet adhesion is poor.

Particles that are too dry and contain crystalline water lose too much to cause lobes, the solution is the same as pine tablets.

Some crystalline drugs are not sufficiently crushed. This kind of medicine can be fully crushed after granulation.

For the lobes caused by too much fine powder and excessive lubricant, part of the air in the powder cannot escape in time and is pressed in the tablet. When the pressure is released, the internal air expansion of the tablet causes the lobes, which can be overcome by screening out part of the fine powder and appropriately reducing the amount of lubricant.

It is reported that the press pressure is too large, the rebound force is large and the sliver; Too fast speed or the die does not meet the requirements, punch length, wear hole in the middle of the die, the middle of the die greater than the upper and lower parts or punch inward edge, can cause the tablets when the ejection caused the crack. Adjust the pressure and speed, improve the matching of the die, check and replace in time.

In addition, pressure chamber low room temperature, low humidity, easy to cause lobes, especially poor viscosity of the drug easy to produce. Adjusting the air-conditioning system can be solved.