When The Capsule Is Filled, The Powder Is Sticky And The Filling Is Unstable. How To Solve This Problem

When The Capsule Is Filled, The Powder Is Sticky And The Filling Is Unstable. How To Solve This Problem

Most of the medicine in the capsule medicine is in powder form, but when filling with the full-automatic capsule filling machine, if the medicine powder is not so dry, it will be unstable. You can try the following methods.

1. If the Chinese medicine is sticky due to moisture absorption, the key is still to pay attention to the extraction process, properly carry out water extraction and alcohol precipitation, improve the process, try to reduce the hygroscopic components brought in, and try to save a part of raw medicine containing more starch together, and participate after damage! Of course, it may also be treated with acrylic resin or the like to reduce moisture absorption.

2. If it is the problem of the excipients in the prescription, the prescription should be adjusted from the beginning. It is suggested that microcrystalline fiber is still helpful to the absorption of the drug powder. The loose excipients or the amount of them should be added, such as changing sucrose to lactose or mannitol to reduce the moisture absorption

3. Add flow aids, such as micro powder silica gel, MgO, magnesium stearate, etc.

4. Dry the powder as much as possible, and the lower the moisture, the better

5. Control the humidity of the workshop to make it as low as possible and the temperature as low as possible

6. Properly add the amount of magnesium stearate.

7. It is necessary to effectively damp proof the drug packaging.

8. The fine point loading capacity of the powder will be better.

9. Check whether the positions of the filling machine module and the metering plate are installed properly. It is better to have less powder in the powder ring, and not too much powder. To fill at high speed, replace the worn filling rod in time. The outer wall of the capsule should be polished and packaged in time.