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It Is More Scientific To Keep The Tablet Machine In Stock

Published:2023-06-06Author:Sources:Views:253


It Is More Scientific To Keep The Tablet Machine In Stock


Tablet press lamination means that two sheets are stacked into one piece. The tablet sticks to the upper punch due to sticking punch or curling of the upper punch. 


At this time, the granules are filled into the die hole and pressed again to form a stack, or because the rising position of the lower punch is too low, the tablet cannot be ejected in time. At the same time, the particles are added into the die hole and repeatedly pressurized. Pressing into laminations makes the tablet press vulnerable to damage, and the problem of sticking punches should be solved to match with the punch, improve the stability of the punching die, and eliminate the failure of the tablet press.


The reasons and treatment of the loose tablet of the tablet press are as follows: loose tablet refers to that after the tablet is pressed, the hardness is not enough, and the surface has pits, and it will be broken when gently pressed with fingers.


Not enough pressure. The solution: Increase the pressure. However, for some large tablets for special purposes, the pressure is relatively high, and if the pressure reaches or exceeds the upper limit of the pressure of the tablet press, it is necessary to customize a tablet press of corresponding specifications with a large pressure. The pressure time is too little and the speed is fast. Correspondingly extend the pressure time, increase the preload, and reduce the speed.


The length of the upper punches of the multi-punch tablet press is uneven. Solution: adjust the punch. The active punch head is loose. Fasten. The fineness of drug crushing is not enough, the content of fibrous or elastic drugs or oil components is too large and the mixing is uneven. It can be overcome by crushing the drug through a 100-mesh sieve, selecting a more viscous binder, appropriately increasing the pressure of the tablet press, and increasing the oily drug absorbent to fully mix it.


The amount of binder or wetting agent is insufficient or improperly selected, so that the particle texture is loose or the particle size distribution is uneven, and the coarse and fine particles are stratified. It can be overcome by choosing an appropriate binder or increasing the dosage, improving the granulation process, mixing more soft materials, and mixing granules.


If the water content of the granules is too small, the over-dried granules have greater elasticity, and the drug containing crystal water loses more crystal water during the drying process of the granules, making the granules brittle and easy to loosen. Therefore, when granulating, the water content of the granules should be controlled according to different varieties. If the granules are too dry, spray an appropriate amount of dilute ethanol (50%-60%), mix well and press into tablets.

The nature of the drug itself. Although the tablet with high density has hardness, it cannot withstand collision and shock. Such as soda tablets, etc. are often prone to loose flakes; low density, poor fluidity, poor compressibility, and re-granulation.

The fluidity of the particles is poor, and the particles filled in the die holes are uneven. There are larger pieces or particles, and debris block the scraper and the discharge port, which affects the filling amount. The particles in the hopper are sometimes more and sometimes less. Granules should be added frequently to keep the stock in the hopper.

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