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The solution to instable powder filling
The solution to instable powder filling
If it is because of moisture obsorption of herbal powder, be careful of extraction process, adopt alcohol extration-water precipitation to improve the technic. Avoid adding Hygroscopic ingredient and retain and add some pulverized starch-containing crude drug,or add acrylic resin reduce hygroscopicity.
If caused by pharmaceutic adjuvant,basically adjust the prescription. Adding AVIRIN can help absorb more powder or adding dispersed adjuvant or increasing the dosage,for example, in order to reduce the obsorption of moisture, use maltose or mannitol to take the place of saccharose.
Adding some materials to improve the fluidity such as Gum Acacia,magnesium oxide and dolomol,etc.
The following are some additional solutions:
I. Keep the powder dry. The drier, the better.
II. Keep the humidity and the temperature low.
III. Increase adding dolomol.
IV. The package must be damp-proof efficiently.
V. If the powder is finer, the content wlii be more precise.
VI. Inspect the position of the filling part and the measuring disk,it’s better not to add too much powder.Fill with high speed and change the worn mould at once. Polish the powder sticked outside of the capsules and pack quickly.
