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Why have and how to deal with broken tablets during pressing
Why have and how to deal with broken tablets during pressing
1.When the pressure is too large, the swelling degree of the particles increases with the pressure, and the combining power of the adhesive can not restrain the expansion. Therefore, the cracking happens, so the pressure should be reduced.
2.The upper punch and the die hole don’t meet the requirement. The die used for a long time is worn , which leads to the inconsistency between the upper punch and the die hole. The upper punch has sharp internal curling edge and the pressure is not uniform, which makes the part of the slice press too high, causing the top crack or the die ring’s deformation.
3.Improper adhesive, adhesive is too less when granulating, lack of cohesive when particles after drying, when powder is excessive, dry particles will be too hard, can cause collapse difficulties, so the adhesive should be appropriately added. Fine powder can be sift out a little if too much; If the particles are too hard, should rework the granulation and add more disintegration agent.
4.Particles are not as required, loose texture and too much fine powder will cause tablet broken. Should adjust the concentration and dosage of adhesives, and improve granulating methods to overcome.
5.Some crystalline drugs have not been fully smashed. This kind of drug can be fully crushed and granulated.
6.The temperature and the humidity is low. It is easy to cause crack, especially in the drug with poor viscosity. Adjust the temperature and humidity system according to the situation.
