Possible problems and solutions during tablet coating

Possible problems and solutions during tablet coating

The coating process of sugarcoating film is complex and takes a long time. There are many problems that are easy to occur, such as cracks, exposed edges, flax surface, flower spots, etc., which can be solved in pharmacy. Sugar coating has been gradually replaced by thin film coating.

(1) the foaming reason is improper curing condition, excessive drying speed, and the film forming condition and appropriate drying speed should be mastered.

(2) the physical and chemical properties of corrugated skin tablets and coating materials affect adhesion. The time interval between adding materials is too short and the amount of spraying fluid is too much. The characteristics of coating materials should be mastered, the interval time should be adjusted, the concentration of coating fluid should be reduced appropriately, and the amount of spraying fluid should be reduced.

(3) the uneven color pigment is not fully mixed with the film coating material, or the plasticizer, pigment and other additives used in the coating prescription are not used properly, and the soluble materials are brought to the surface of the film when drying. Thin film coating materials can be mixed into dilute solution several times, or pigment and thin film coating materials in the colloid mill or grinding uniform, fine after adding. Adjust air and temperature and slow down drying rate.

(4) insufficient coating strength, inappropriate proportion of coating material, low adhesive strength of coating and drug, and insufficient thickness of coating. Change the formula and increase the thickness of the coating.

Enteric membrane coating, in addition to the above problems, but also: in the stomach has been disintegrated. The reason is the improper selection or proportion of enteric coating materials, low adhesion strength between the coating and the drug, and insufficient or uneven layer of coating. Suitable materials should be selected and appropriate proportion should be obtained to increase the coating layer and make the coating evenly. The reason is that the intestinal coating material is not properly selected and the layer is too thick, which changes during storage and is related to the penetration of gastric juice. When the gastric juice infiltrates into the heart of the tablet, the disc expands, and when it enters the intestinal liquid, the intestine dissolves but the disc heart only expands slightly but not completely disintegrates. It can be solved by adjusting the proportion of enteric coated materials, mastering the coating level, choosing proper disintegrating agent such as carboxymethyl starch instead of starch or adding a small amount of microcrystalline cellulose to make granule.

Guangdong Rich Packing professional production coating machine, if you need to contact us.