Problems and possible solutions in tablet pressing process

Problems and possible solutions in tablet pressing process

The following is the Guangdong Rich Packing in the use of tablet pressing machine process summed up the use of tablet pressing may occur problems and solutions for your reference:

1 pine

The viscosity of the material is not enough (too much raw powder) - re granulating with adhesive.

There are too many oily ingredients in the raw materials, which are added to the absorbent (CaHPO4, CaCO3, etc.).

If it is invalid, it will deoiling.

The water content of granules is not proper. Particles are dry and wet, and the particles are deformed. 3%-5% is suitable for water content.

Ethanol concentration is too high in pelleting; punch length is not uniform; tablet pressure after exposure to air for too long, water swelling will also produce loose tablets.

2 Sticky punching

The particles are too wet, the amount of lubricants is not enough or the distribution is uneven.

3 disintegration time limit: pressure and hardness are important factors that affect the time limit of disintegration.

Effect of starch: starch can disintegrate insoluble or hydrophobic drugs quickly, but the effect of water-soluble drugs is poor.

The adhesive force is strong and the dosage is large, so that the time limit for disintegration is beyond the limit.

The amount of lubricants used can make the disintegration time exceed the limit.

The sugar containing tablets obviously prolonged the disintegration when the storage temperature was high or the moisture was wet.

4 lobes:

Excessive fineness or insufficient adhesives or too fine particles can result in splitting - sieving fine powder, drying adhesives and evenly pressing tablets (CMC, microcrystalline cellulose, etc.).

More oil and more fiber -- absorbent or sugar powder.

Granular water content is small, dry - spray ethanol to absorb moisture;

Excessive pressure or excessive speed.

The difference between 5 pieces of weight is out of gauge: uneven particle size, unbalanced feeder, and inflexible undershoot.

6 stack tablets: stick-punch or up-punch edge curling, etc. cause the tablets to stick in the up-punch, down-punch rising position is too low.

7 discoloration or surface spots: fine particles, uneven lubricants, too much oil.

Guangdong Rich Packing specializes in the production and sale of tablet press. If necessary, please contact us.