Technology and principle of tablet press machine in pharmaceutical industry

Technology and principle of tablet press machine in pharmaceutical industry

The working process of the tablet press

The working process of the tablet press can be divided into the following steps:

1. The punch part of the powder pressing machine (its working position is upward) is extended into the middle die hole from the lower end to seal the bottom of the middle die hole;

2. Fill materials (powder and particle) into the middle die hole with feeder;

3. The punch part (with its working position downward) on the pharmaceutical tablet press falls into the middle die hole from the upper end, and has a certain downward stroke to press the powder into tablets;

4. Up-punch and lift the hole. Push down and push up to push the tablet out of the middle die hole to complete the tablet pressing process.

5. Drop down to the original position and prepare for the next filling.

Pharmaceutical press sheet mechanism sheet principle

1. Dose control

Various tablets have different dosage requirements, and large dosage adjustment is achieved by selecting different punch diameters. After the die size is selected, the minute dose adjustment is to adjust the actual length of the die hole after the back cover by adjusting the depth of the punch hole, so as to adjust the filling volume of the drug in the die hole. Therefore, there should be a mechanism to adjust the original position of the punch in the die hole in the tablet press to meet the requirements of dose adjustment.

2. Control of tablet thickness and degree of compaction

The dosage of a drug is determined by prescription and pharmacopoeia and cannot be changed. For storage, storage, and disintegration time limits, a certain dose of pressure is required for tablet pressing, which will also affect the actual thickness and appearance of the tablet. Pressure adjustment is essential during tablet pressing. This is achieved by adjusting the amount of downstroke in the die hole. Some presser in the process of presser not only have up and down action, but also can have up and down action, by up and down relative motion to complete the process of presser. But the pressure regulation is mostly realized by adjusting the mechanism of the amount of upward thrust and downward pressure.