Characteristics and Technology of Four Common Solid Formations

Pharmaceutical dosage forms can be divided into liquid dosage forms, gas dosage forms, solid dosage forms and semi-solid dosage forms according to their forms. Among them, powder (powder), granule, capsule and tablet are common solid dosage forms. The characteristics and process of these commonly used solid preparations are briefly introduced. Powder is a powder preparation made of one or more drugs. The general process of powder preparation includes material pretreatment, crushing, screening, mixing, batching, quality inspection, packaging and storage. Among them, material pretreatment refers to the material treatment that meets the crushing requirements. In the grinding and screening process, the raw materials and auxiliary materials used for grinding must be crushed unless they are used at the specified level. 

In the process of packaging and storage, the focus of powder packaging and storage is moisture-proof, because the powder has great dispersion, moisture absorption and weather resistance. In the process of quality inspection, we need to check the uniformity, humidity, load difference, etc. Granule is a kind of dry granule with a certain particle size which is made of medicine and suitable auxiliary materials. It is characterized by direct swallowing or washing, easy to carry, rapid dissolution and absorption. The preparation of granules usually adopts the main step of wet granulation. The process includes crushing, screening, mixing, soft material manufacturing, granulating, drying, granulating, grading or coating, batching and packaging. Among them, the soft material is made by mixing the drug with appropriate diluent and disintegrating agent, adding water or other adhesives. Wet particles are made by pressing the soft material through the sieve manually or mechanically. 

Common drying methods include box drying and fluidized bed drying. In the whole wheat classification process, the whole wheat screening and classification methods are generally used. In the coating process, the aim is to achieve taste correction, correction, stability, sustained release, controlled release or enteric coating. Particles can be coated, and film coating is usually used. When storing particles, attention should be paid to maintaining their uniformity. Sealed package and store in a dry place to prevent moisture deterioration. The quality inspection of particles should be carried out from the aspects of appearance, particle size, dry weight loss and chemical load difference of particle dissolution. Capsules include hard capsules and soft capsules. Hard capsules are solid preparations made by filling drugs into hollow hard capsules or sealing them in elastic soft capsules. Hard capsules can cover up the smell of drugs, improve the stability of drugs, and protect the efficacy of drugs. 

Capsule coating can also achieve the purpose of local release. The production of hard capsules can be divided into two aspects: the preparation of capsule shell and the filling of drugs. The process includes crushing, screening, mixing, capsule filling, capsule dedusting, cleaning, inspection and packaging of each component. Quality inspection includes appearance, moisture, volume difference, disintegration and dissolution, packaging and storage. Compared with hard capsule, soft capsule has stronger plasticity and elasticity. Tablets are round or heterogeneous tablet like solid preparations formed by mixing drugs with appropriate excipients through preparation technology.

Tablet production needs to use tablet pressing equipment for processing. The coating machine is used to coat and complete the drug packaging. Guangdong Ruiqi Packaging Machinery Co., Ltd. specializes in R & D and production of medical packaging machinery and equipment. It operates automatic rotary tablet press, capsule filling machine, electronic granulator, bubble packaging machine, etc. packaging machine and other products are essential for drug packaging. Necessary production equipment. For example, the powder or particles are pressed into tablets by a tablet press, and the powder and particles are filled into hard capsules by a capsule filling machine.

Guangdong Ruiqi Packaging Machinery Co., Ltd. is a professional a supply enterprise with 27 years of production experience and 15 years of export experience.